Berberine: "natural Ozempic" or fashion myth?

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What is berberine and why is it spoken of as "nature's Ozempic"
20:00, 05.09.2025

Berberine is the new favourite remedy of health enthusiasts.



This plant extract, obtained from the roots and bark of some plants, has gone viral on TikTok, where it is called "natural Ozempic" - in honour of the famous weight-loss drug. However, experts warn: such a comparison is not quite correct, although the interest in the substance is quite justified, reports Harper's Bazaar India.

What berberine does

Berberine is a plant-derived yellow alkaloid found in the roots, stems and bark of plants such as barberry, goldenseal and Oregon grape. It is known for its antimicrobial, anti-inflammatory, metabolically regulating and antioxidant properties. Berberine is being studied for its potential effects on controlling blood sugar and cholesterol levels, supporting gut health, and may also be used as an aid for diarrhoea and weight management.

According to health expert and founder of the JSHealth Vitamins brand Jessica Sepel, berberine "works at the cellular level to support glucose metabolism and insulin sensitivity." This is especially important for stable energy levels, mood, and overall metabolism.

When blood sugar levels are normal, a person is less likely to suffer from energy loss, mood swings and cravings for sweets - problems that often go unnoticed but greatly affect daily well-being.

How appropriate is the comparison with Ozempic?

While the name "natural Ozempic" sounds spectacular, Sepel cautions against taking it literally:

"It's a simplification. Yes, research confirms that berberine affects sugar levels and can affect body composition, but it works very differently than products like Ozempic," she explains.

'Berberine can be part of a holistic approach to metabolic health, but it is not a substitute for medical drugs or a 'magic pill'.

What you can combine berberine with

Sepel recommends combining berberine with chromium, a micronutrient important for metabolising carbohydrates and maintaining normal blood glucose levels.

"Together, they can work synergistically to support energy, appetite and metabolism," she says.

However, it's always a good idea to pay attention to the composition of a supplement and consult your doctor.

Sepel notes that her philosophy of wellness formulas is closely tied to feedback from customers:

"If people complain of a decline in energy or cravings for sweets, we take that into account when creating new products."

What to expect from berberine

Like most natural remedies, berberine doesn't have an instant effect. Noticeable results appear with regular use, combined with proper diet and lifestyle.

"It can help with stable energy, reduced cravings for sweets and a balanced appetite, but don't expect quick miracles," Sepel emphasises.

Berberine is not recommended for pregnant and breastfeeding women. It can also interact with medications, especially for diabetes and blood pressure. It is important to consult a doctor before taking it.

Overall, Sepel advises that supplement use should be approached individually and responsibly: "The best thing to do is to discuss with a qualified professional whether it is right for you."

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Maria Grynevych

Maria Grynevych, project manager, journalist, co-author of Guidebook Sacred Mountains of the Dnieper Region, Lecture Course: Cult Topography of the Middle Dnieper Region.